Peppers Ferry Road (I-77 / I-81 Crossroads)
On Peppers Ferry Road at the I-77 and I-81 interstate crossroads, Comfort Suites Wytheville (4.4, 646 reviews) is the town's single hot-tub-search hotel — a well-rated Comfort Suites with a pool, free breakfast, business-class rooms, fitness center and meeting rooms. Subratings run 4.4–4.6 with strong service and cleanliness; repeat guests praise the friendly owner who keeps the property well-maintained. Best for I-81 and I-77 interstate travelers wanting a reliable brand pool hotel with a friendly-owner reputation.